Congratulations on Dr. Xian Xie’s excellent work published in JACS
Recently, our team’s collaborative work has been published online in the Journal of the American Chemical Society (JACS). Two former postdoctoral fellows of Lin Lab, Dr. Xian Xie and Dr. Xu Yan, contributed equally to this work. Congratulations to them! This work is a collaboration with Prof. Liming Bian’s team from South China University of Technology.
Our study presents a gelatin-based, tunable coacervate matrix that mimics the dynamic biophysical cues of the embryonic extracellular matrix (ECM) to regulate stem cell fate. Utilizing liquid-liquid phase separation, this system supports stemness during the pre-implantation stage and promotes invasive behaviors via a stiffening coacervate-hydrogel transition, offering a versatile platform for developmental modeling.
The Journal of the American Chemical Society, founded in 1879, is the flagship journal of the American Chemical Society and the world’s preeminent journal of chemistry and interfacing areas of science.
The journal impact factor is 15.7 (2024).
Publication link:
https://pubs.acs.org/doi/10.1021/jacs.5c16913
Congratulations on Mr. Hongqi Zhao’s excellent work published in Advanced Composites and Hybrid Materials
Recently, Mr. Hongqi Zhao, a PhD student (CUHK) from Lin lab and colleagues from Tongji Hospital of Huazhong University of Science and Technology published their excellent work in Advanced Composites and Hybrid Materials. Congratulations!
Osteoarthritis (OA) is a chronic joint disorder characterized by synovial inflammation, cartilage degradation and macrophage polarization imbalance, where excessive reactive oxygen species (ROS) accumulation and mitochondrial dysfunction exacerbate pro-inflammatory M1 macrophage polarization. The team has developed a pH-responsive selenium-doped MgAl-layered double hydroxide nanocomposite (Se/LDH@PEG-M) loaded with mitochondrial-targeted Mito-TEMPO for OA therapy. In the acidic OA microenvironment, it degrades to release selenium, Mg²⁺, and the ROS scavenger. The material exhibits glutathione peroxidase (GPX)-like antioxidant activity, effectively scavenges ROS, inhibits pro-inflammatory M1 macrophage polarization, promotes anti-inflammatory M2 shift, and restores mitochondrial OXPHOS and ATP production. In vitro, it suppressed inflammatory pathways and protected chondrocytes from apoptosis and catabolism. In murine OA models, intra-articular injection significantly reduced synovitis, osteophyte formation, and cartilage degradation, demonstrating a promising multifunctional approach via ROS scavenging, inflammation suppression, and macrophage metabolism reprogramming.
Advanced Composites and Hybrid Materials (Journal Impact Factor 21.8, 2024) is a single-blind peer-reviewed journal focused on composites and nanocomposites, their design, modeling, advanced manufacturing, interface engineering technologies and applications.
Congratulations to Dr. Sien Lin for being appointed as International Editorial Board member of Journal of Orthopaedic Translation (JOT) from 2026 to 2029.
About JOT
The Journal of Orthopaedic Translation (JOT) is co-edited by Prof. Ling Qin of The Chinese University of Hong Kong and Prof. Regis James O’Keefe of Washington University School of Medicine.
JOT achieved an Impact Factor of 7.8 in 2024, ranking 3rd among 139 journals in Orthopaedics. The journal’s 2024 CiteScore is 13.5, ranking 5th among 332 journals in Orthopedics and Sports Medicine (top 2%).
According to the latest CAS Journal Ranking, JOT is listed in the Q1 category in both Medicine and Orthopaedics.
Recent articles of JOT:
https://www.sciencedirect.com/journal/journal-of-orthopaedic-translation/issues
Dr. Sien Lin Shares Grant Application Insights at Spine Surgeons Annual Meeting
Dr. Sien Lin was invited to present at the Annual Meeting of Spine Surgeons, hosted by the Huizhou Medical Association in Guangdong this December. During the conference, Dr. Lin shared valuable insights and practical strategies drawn from extensive experience in navigating the grant application process. The presentation provided attending spine surgeons with essential guidance on securing research funding, highlighting best practices for proposal development and common pitfalls to avoid. This knowledge-sharing session was well-received by colleagues and reflects Dr. Lin’s commitment to advancing the field of spine surgery through collaborative learning and research excellence.
Dr. Qi Zhang from Leader Med-Biotech Visits Laboratory
In December 2025, we had the pleasure of welcoming Dr. Qi Zhang from Leader Med-Biotech to our laboratory. During the visit, Dr. Zhang toured our research facilities and engaged in productive discussions with our team regarding ongoing projects and potential areas of collaboration. The visit provided an excellent opportunity to exchange ideas on the latest developments in medical biotechnology and explore synergies between our research initiatives and Leader Med-Biotech’s innovative work in the field. We look forward to building upon this connection and fostering future partnerships that advance our shared commitment to medical research and innovation.
Prof. Sherry Yan Yan Huang from Cambridge University Visits Department and Laboratory
We were honored to host Prof. Sherry Yan Yan Huang from the Department of Engineering at Cambridge University during her visit to our department and laboratory in December 2025. Prof. Huang toured our research facilities and engaged in productive discussions with faculty members and students about potential collaborative opportunities. The visit strengthened our international academic ties and opened exciting possibilities for future joint research endeavors between our institutions.
Dr. Sien Lin Receives JOT Excellent Reviewer Award
Dr. Sien Lin has been honored with the JOT Excellent Reviewer Award 2025 in recognition of outstanding contributions to the peer review process. This prestigious award acknowledges Dr. Lin’s dedication to maintaining high standards of scientific rigor and providing thoughtful, constructive feedback to the Journal of Orthopaedic Translation. The recognition highlights Dr. Lin’s commitment to advancing orthopaedic research and supporting the academic community.
Dr. Wende Li from Department of Science and Technology Visits Laboratory
In November 2025, we welcomed Dr. Wende Li from the Department of Science and Technology of Guangdong Province to our laboratory. During the visit, Dr. Li toured our research facilities and engaged in discussions with our team about current projects and research directions. The visit provided a valuable opportunity to showcase our work and explore potential support mechanisms for advancing scientific innovation in the region.
Dr. Sien Lin Presents Research at ICORS World Congress in Adelaide
Dr. Sien Lin presented his research at the ICORS World Congress of Orthopaedic Research held in Adelaide in October 2025. The presentation showcased Dr. Lin’s latest findings to an international audience of leading orthopaedic researchers and clinicians. Participating in this prestigious global forum provided an excellent platform to share innovative work, exchange ideas with colleagues from around the world, and contribute to advancing the field of orthopaedic research.
Dr. Sien Lin Presents at International Summit Forum on Tissue Engineering
Dr. Sien Lin presented his research at the 4th International Summit Forum on Tissue Engineering and Regenerative Medicine held in Zhengzhou, Henan in September 2025. The presentation highlighted Dr. Lin’s latest work to an international audience of experts in tissue engineering and regenerative medicine. Participating in this summit provided a valuable platform to share innovative findings, engage with leading researchers in the field, and contribute to advancing regenerative medicine research.
Congratulations to Dr. Jiaming Yang on Successful PhD Defence
Congratulations to Dr. Jiaming Yang for successfully passing his PhD defence in August 2025. This significant milestone marks the culmination of years of dedicated research and scholarly work. We are proud of Dr. Yang’s achievements and the contributions he has made to our research community. We wish him continued success in his future academic and professional endeavors.
Dr. Sien Lin Presents Research at 11th APICA 2025 in Guangzhou
Dr. Sien Lin presented his research at the 11th Asia-Pacific Conference on Integrated Care (APICA) 2025 held in Guangzhou in August 2025. The presentation shared Dr. Lin’s latest findings with an international audience of healthcare professionals and researchers. Participating in this regional conference provided an excellent opportunity to contribute to discussions on integrated care and collaborate with colleagues across the Asia-Pacific region.
Dr. Sien Lin Presents at International Conference on Mechanobiology
Dr. Sien Lin presented his research at the International Conference on Mechanobiology held in Shanghai in July 2025. The presentation showcased Dr. Lin’s latest findings to an international audience of mechanobiology researchers and scientists. Participating in this conference provided a valuable platform to share innovative work, engage with leading experts in the field, and contribute to advancing our understanding of mechanobiology.
Congratulations to Dr. Xu Yan on Successful PhD Defenc
Congratulations to Dr. Xu Yan for successfully passing his PhD defence in July 2025. This remarkable achievement represents the culmination of years of rigorous research, hard work, and dedication to advancing scientific knowledge. Dr. Yan has made valuable contributions to our research community throughout his doctoral studies, and his successful defence marks an important milestone in his academic journey. We are incredibly proud of his accomplishments and look forward to seeing his continued impact in the field. We wish him all the best in his future academic and professional endeavors.
Dr. Sien Lin Presents and Co-Chairs Session at EORS in Davos
Dr. Sien Lin presented his research and co-chaired a session at the European Orthopaedic Research Society (EORS) conference held in Davos in June 2025. In addition to showcasing his latest findings, Dr. Lin’s role as session co-chair demonstrated his growing leadership within the international orthopaedic research community. The conference provided an excellent platform to engage with leading European researchers, facilitate important scientific discussions, and contribute to advancing the field of orthopaedic research.
Dr. Sien Lin Presents Research at CORMed 2025 in Suzhou
Dr. Sien Lin presented his research at CORMed 2025 held in Suzhou, China. The presentation showcased Dr. Lin’s latest findings to an audience of researchers and professionals in the field. Participating in this conference provided a valuable opportunity to share innovative work, exchange ideas with colleagues, and contribute to advancing medical research in the region.
Stanford Alumni Reunion at EORS Conference in Davos
Stanford alumni gathered for a special reunion at the European Orthopaedic Research Society (EORS) conference in Davos in 2025. The reunion brought together former Stanford researchers and faculty, including Prof. Sien Lin, providing an opportunity to reconnect, share updates on current research, and strengthen the Stanford network within the international orthopaedic research community. The gathering highlighted the continued impact of Stanford alumni in advancing the field and fostered opportunities for future collaborations.
